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Genomic Approach to Understanding TCDD Toxicity in Zebrafish
This continuing project will address gene expression changes in zebrafish associated with TCDD exposures. Besides being nearly transparent, the zebrafish is the first fish to have had its genome mapped, which makes it ideal for research on the genetic effects of exposure to toxic contaminants. The goal of the project is to determine whether different TCDD responses in tissues correspond to a distinct gene expression pattern. Using DNA microarrays, the investigators hope to determine whether gene expression patterns can be used to predict sublethal toxicity; if successful, the microarray approach may be used as a screening tool to predict responses in wild fishes. This work directly addresses the strategic priority of developing gene microarrays in fish for identifying alterations in gene expression associated with chemical and physical stresses.
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